7F97

Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97

Summary for 7F97

• Entry DOI: 10.2210/pdb7f97/pdb
• Descriptor: Proline--tRNA ligase, PROLINE, 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ... (7 entities in total)
• Functional Keywords: protein translation, malaria, inhibitor, prs, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Plasmodium falciparum 3D7
• Total number of polymer chains: 4
• Total formula weight: 234138.22

Authors

Mishra, S.,Malhotra, N.,Yogavel, M.,Sharma, A. (deposition date: 2021-07-04, release date: 2023-01-04, Last modification date: 2024-07-31)

• Primary citation: Mishra, S.,Malhotra, N.,Laleu, B.,Chakraborti, S.,Yogavel, M.,Sharma, A.; ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development; Iscience, 27:-, 2024; DOI: 10.1016/j.isci.2024.110049

Experimental method

X-RAY DIFFRACTION (2.394 Å)