7F97

Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97

7F97 の概要

• エントリーDOI: 10.2210/pdb7f97/pdb
• 分子名称: Proline--tRNA ligase, PROLINE, 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ... (7 entities in total)
• 機能のキーワード: protein translation, malaria, inhibitor, prs, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Plasmodium falciparum 3D7
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 234138.22

構造登録者

Mishra, S.,Malhotra, N.,Yogavel, M.,Sharma, A. (登録日: 2021-07-04, 公開日: 2023-01-04, 最終更新日: 2024-07-31)

• 主引用文献: Mishra, S.,Malhotra, N.,Laleu, B.,Chakraborti, S.,Yogavel, M.,Sharma, A.; ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development; Iscience, 27:-, 2024; DOI: 10.1016/j.isci.2024.110049

実験手法

X-RAY DIFFRACTION (2.394 Å)