7F8W

Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq

Summary for 7F8W

• Entry DOI: 10.2210/pdb7f8w/pdb
• EMDB information: 31493 31494
• Descriptor: Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: g protein-coulped receptor, cholecystokinin receptor cckbr, gastrin-17, structural protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 169202.86

Authors

Zhang, X.,He, C.,Wang, M.,Zhou, Q.,Yang, D.,Zhu, Y.,Wu, B.,Zhao, Q. (deposition date: 2021-07-02, release date: 2021-10-13, Last modification date: 2022-02-16)

• Primary citation: Zhang, X.,He, C.,Wang, M.,Zhou, Q.,Yang, D.,Zhu, Y.,Feng, W.,Zhang, H.,Dai, A.,Chu, X.,Wang, J.,Yang, Z.,Jiang, Y.,Sensfuss, U.,Tan, Q.,Han, S.,Reedtz-Runge, S.,Xu, H.E.,Zhao, S.,Wang, M.W.,Wu, B.,Zhao, Q.; Structures of the human cholecystokinin receptors bound to agonists and antagonists.; Nat.Chem.Biol., 17:1230-1237, 2021; PubMed: 34556863; DOI: 10.1038/s41589-021-00866-8

Experimental method

ELECTRON MICROSCOPY (3.1 Å)