7F8P
Crystal structure of the Mycobacterium tuberculosis L,D-transpeptidase-2 (LdtMt2) with new carbapenem drug T203
Summary for 7F8P
| Entry DOI | 10.2210/pdb7f8p/pdb |
| Descriptor | L,D-transpeptidase 2, (2R,3R)-3-methyl-4-(2-oxidanylidene-2-propan-2-yloxy-ethyl)sulfanyl-2-[(2R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]-2,3-dihydro-1H-pyrrole-5-carboxylic acid, GLYCEROL, ... (6 entities in total) |
| Functional Keywords | l, d-transpeptidase, cysteine protease, hydrolase |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Total number of polymer chains | 2 |
| Total formula weight | 80176.23 |
| Authors | Kumar, P.,Lamichhane, G. (deposition date: 2021-07-02, release date: 2022-05-11, Last modification date: 2023-11-29) |
| Primary citation | Ahmad, N.,Dugad, S.,Chauhan, V.,Ahmed, S.,Sharma, K.,Kachhap, S.,Zaidi, R.,Bishai, W.R.,Lamichhane, G.,Kumar, P. Allosteric cooperation in beta-lactam binding to a non-classical transpeptidase. Elife, 11:-, 2022 Cited by PubMed: 35475970DOI: 10.7554/eLife.73055 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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