7F55

Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex

7F55 の概要

• エントリーDOI: 10.2210/pdb7f55/pdb
• EMDBエントリー: 31456 31457 31458 31461
• 分子名称: Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
• 機能のキーワード: single particle, membrane protein, class a g-protein-coupled receptors
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 164683.48

構造登録者

Zhang, H.,Chen, L.,Mao, C.,Shen, Q.,Yang, D.,Shen, D.,Qin, J. (登録日: 2021-06-21, 公開日: 2021-11-03, 最終更新日: 2022-02-16)

• 主引用文献: Zhang, H.,Chen, L.N.,Yang, D.,Mao, C.,Shen, Q.,Feng, W.,Shen, D.D.,Dai, A.,Xie, S.,Zhou, Y.,Qin, J.,Sun, J.P.,Scharf, D.H.,Hou, T.,Zhou, T.,Wang, M.W.,Zhang, Y.; Structural insights into ligand recognition and activation of the melanocortin-4 receptor.; Cell Res., 31:1163-1175, 2021; PubMed: 34433901; DOI: 10.1038/s41422-021-00552-3

実験手法

ELECTRON MICROSCOPY (3.1 Å)