7F49

von Willebrand factor (VWF) A1 domain with BT-100 aptamer RNA

7F49 の概要

• エントリーDOI: 10.2210/pdb7f49/pdb
• 分子名称: von Willebrand factor, BT-100, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: aptamers, arterial thrombosis, platelets, primates, von willebrand factor, blood clotting
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34121.49

構造登録者

Zhu, S. (登録日: 2021-06-18, 公開日: 2021-07-07, 最終更新日: 2024-11-06)

主引用文献

Zhu, S.,Gilbert, C.J.
The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer
J Thromb Haemost., 18:1113-1123, 2020

PubMed Abstract: Thrombus formation involves coagulation proteins and platelets. The latter, referred to as platelet-mediated thrombogenesis, is predominant in arterial circulation. Platelet thrombogenesis follows vascular injury when extracellular von Willebrand factor (VWF) binds via its A3 domain to exposed collagen, and the free VWF A1 domain binds to platelet glycoprotein Ib (GPIb).

PubMed: 32011054
DOI: 10.1111/jth.14755

実験手法

X-RAY DIFFRACTION (2.09 Å)