7F46

Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab (state1, local refinement of the RBD, NTD and 35B5 Fab)

7F46 の概要

• エントリーDOI: 10.2210/pdb7f46/pdb
• EMDBエントリー: 31444
• 分子名称: Spike glycoprotein, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ... (4 entities in total)
• 機能のキーワード: immune system, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 334342.24

構造登録者

Wang, X.F.,Zhu, Y.Q. (登録日: 2021-06-17, 公開日: 2022-03-23, 最終更新日: 2022-09-21)

• 主引用文献: Wang, X.,Hu, A.,Chen, X.,Zhang, Y.,Yu, F.,Yue, S.,Li, A.,Zhang, J.,Pan, Z.,Yang, Y.,Lin, Y.,Gao, L.,Zhou, J.,Zhao, J.,Li, F.,Shi, Y.,Huang, F.,Yang, X.,Peng, Y.,Tu, L.,Zhang, H.,Zheng, H.,He, J.,Zhang, H.,Xu, L.,Huang, Q.,Zhu, Y.,Deng, K.,Ye, L.; A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD; Signal Transduct Target Ther, 7:114-, 2022; DOI: 10.1038/s41392-022-00954-8

実験手法

ELECTRON MICROSCOPY (4.79 Å)