7F3Z

Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP

Summary for 7F3Z

• Entry DOI: 10.2210/pdb7f3z/pdb
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (6 entities in total)
• Functional Keywords: pfdhfr, trimethoprim, dihydrofolate reductase, plasmodium falciparum, structural protein
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 2
• Total formula weight: 146690.19

Authors

Vanichtanankul, J.,Tanramluk, D.,Chitnumsub, P.,Yuvaniyama, J.,Yuthavong, Y. (deposition date: 2021-06-17, release date: 2021-09-22, Last modification date: 2023-11-29)

• Primary citation: Tanramluk, D.,Pakotiprapha, D.,Phoochaijaroen, S.,Chantravisut, P.,Thampradid, S.,Vanichtanankul, J.,Narupiyakul, L.,Akavipat, R.,Yuvaniyama, J.; MANORAA: A machine learning platform to guide protein-ligand design by anchors and influential distances.; Structure, 30:181-189.e5, 2022; PubMed: 34614393; DOI: 10.1016/j.str.2021.09.004

Experimental method

X-RAY DIFFRACTION (2.6 Å)