7F3Z
Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP
7F3Z の概要
エントリーDOI | 10.2210/pdb7f3z/pdb |
分子名称 | Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (6 entities in total) |
機能のキーワード | pfdhfr, trimethoprim, dihydrofolate reductase, plasmodium falciparum, structural protein |
由来する生物種 | Plasmodium falciparum |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 146690.19 |
構造登録者 | Vanichtanankul, J.,Tanramluk, D.,Chitnumsub, P.,Yuvaniyama, J.,Yuthavong, Y. (登録日: 2021-06-17, 公開日: 2021-09-22, 最終更新日: 2023-11-29) |
主引用文献 | Tanramluk, D.,Pakotiprapha, D.,Phoochaijaroen, S.,Chantravisut, P.,Thampradid, S.,Vanichtanankul, J.,Narupiyakul, L.,Akavipat, R.,Yuvaniyama, J. MANORAA: A machine learning platform to guide protein-ligand design by anchors and influential distances. Structure, 30:181-189.e5, 2022 Cited by PubMed: 34614393DOI: 10.1016/j.str.2021.09.004 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
構造検証レポート
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