7F3M

Crystal structure of FGFR4 kinase domain with PRN1371

7F3M の概要

• エントリーDOI: 10.2210/pdb7f3m/pdb
• 分子名称: Fibroblast growth factor receptor 4, 6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, complex, structural protein, transferase-transferase inhibitor complex, transferase-transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35544.71

構造登録者

Chen, X.J.,Qu, L.Z.,Dai, S.Y.,Wei, H.D.,Chen, Y.H. (登録日: 2021-06-16, 公開日: 2022-01-12, 最終更新日: 2023-11-29)

• 主引用文献: Qu, L.,Chen, X.,Wei, H.,Guo, M.,Dai, S.,Jiang, L.,Li, J.,Yue, S.,Chen, Z.,Chen, Y.; Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors; Commun Chem, 5:5-, 2022; DOI: 10.1038/s42004-021-00623-x

実験手法

X-RAY DIFFRACTION (2.289 Å)