7F3B
cocrystallization of Escherichia coli dihydrofolate reductase (DHFR) and its pyrrolo[3,2-f]quinazoline inhibitor.
Summary for 7F3B
Entry DOI | 10.2210/pdb7f3b/pdb |
Descriptor | Dihydrofolate reductase, 7-[(2-fluorophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine, GLYCEROL (3 entities in total) |
Functional Keywords | folate pathway, dihydrofolate reductase, catalyze the reduction of dihydrofolate to tetrahydrofolate, antibiotic |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 1 |
Total formula weight | 19339.74 |
Authors | Wang, H.,You, X.F.,Yang, X.Y.,Li, Y.,Hong, W. (deposition date: 2021-06-16, release date: 2022-04-27, Last modification date: 2023-11-29) |
Primary citation | Li, Y.,Ouyang, Y.,Wu, H.,Wang, P.,Huang, Y.,Li, X.,Chen, H.,Sun, Y.,Hu, X.,Wang, X.,Li, G.,Lu, Y.,Li, C.,Lu, X.,Pang, J.,Nie, T.,Sang, X.,Dong, L.,Dong, W.,Jiang, J.,Paterson, I.C.,Yang, X.,Hong, W.,Wang, H.,You, X. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur.J.Med.Chem., 228:113979-113979, 2022 Cited by PubMed: 34802838DOI: 10.1016/j.ejmech.2021.113979 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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