7F2K

Crystal structure of PDE4D catalytic domain complexed with compound 17a

7F2K の概要

• エントリーDOI: 10.2210/pdb7f2k/pdb
• 分子名称: Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: pde4 inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116883.47

構造登録者

Huang, Y.-Y.,He, X.,Luo, H.-B. (登録日: 2021-06-11, 公開日: 2021-10-20, 最終更新日: 2023-11-29)

• 主引用文献: Huang, Y.Y.,Deng, J.,Tian, Y.J.,Liang, J.,Xie, X.,Huang, Y.,Zhu, J.,Zhu, Z.,Zhou, Q.,He, X.,Luo, H.B.; Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.; J.Med.Chem., 64:13736-13751, 2021; PubMed: 34520193; DOI: 10.1021/acs.jmedchem.1c01085

実験手法

X-RAY DIFFRACTION (2.10001966681 Å)