7EW2

Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein

Summary for 7EW2

• Entry DOI: 10.2210/pdb7ew2/pdb
• EMDB information: 31345
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: complex, agonist, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 162878.15

Authors

Zhao, C.,Wang, W.,Wang, H.L.,Shao, Z.H. (deposition date: 2021-05-24, release date: 2021-09-29, Last modification date: 2025-07-02)

• Primary citation: Zhao, C.,Cheng, L.,Wang, W.,Wang, H.,Luo, Y.,Feng, Y.,Wang, X.,Fu, H.,Cai, Y.,Yang, S.,Fu, P.,Yan, W.,Shao, Z.; Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes.; Cell Res., 32:218-221, 2022; PubMed: 34545189; DOI: 10.1038/s41422-021-00567-w

Experimental method

ELECTRON MICROSCOPY (3.1 Å)