7ER2
Crystal structure of EGFR 696-1022 T790M/C797S in complex with LS_2_40
Summary for 7ER2
Entry DOI | 10.2210/pdb7er2/pdb |
Descriptor | Epidermal growth factor receptor, 5-chloranyl-N2-[3-chloranyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine (3 entities in total) |
Functional Keywords | egfr, t790m/c797s, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38048.88 |
Authors | |
Primary citation | Li, S.,Zhang, T.,Zhu, S.J.,Lei, C.,Lai, M.,Peng, L.,Tong, L.,Pang, Z.,Lu, X.,Ding, J.,Ren, X.,Yun, C.H.,Xie, H.,Ding, K. Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR T790M/C797S Mutants. Acs Med.Chem.Lett., 13:196-202, 2022 Cited by PubMed: 35178175DOI: 10.1021/acsmedchemlett.1c00555 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.662 Å) |
Structure validation
Download full validation report