7EO2
Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to FTY720p
Summary for 7EO2
Entry DOI | 10.2210/pdb7eo2/pdb |
EMDB information | 31225 |
Descriptor | Sphingosine 1-phosphate receptor 1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total) |
Functional Keywords | gpcr, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 151143.19 |
Authors | |
Primary citation | Xu, Z.,Ikuta, T.,Kawakami, K.,Kise, R.,Qian, Y.,Xia, R.,Sun, M.X.,Zhang, A.,Guo, C.,Cai, X.H.,Huang, Z.,Inoue, A.,He, Y. Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18:281-288, 2022 Cited by PubMed: 34937912DOI: 10.1038/s41589-021-00930-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.89 Å) |
Structure validation
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