7EJV

The co-crystal structure of DYRK2 with YK-2-69

7EJV の概要

• エントリーDOI: 10.2210/pdb7ejv/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone, ... (4 entities in total)
• 機能のキーワード: phosphorylase kinase, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90842.83

構造登録者

Li, Z.,Xiao, Y.,Yuan, K.,Kuang, W.,Xiuquan, Y.,Yang, P. (登録日: 2021-04-02, 公開日: 2022-04-06, 最終更新日: 2023-11-29)

• 主引用文献: Yuan, K.,Li, Z.,Kuang, W.,Wang, X.,Ji, M.,Chen, W.,Ding, J.,Li, J.,Min, W.,Sun, C.,Ye, X.,Lu, M.,Wang, L.,Ge, H.,Jiang, Y.,Hao, H.,Xiao, Y.,Yang, P.; Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.; Nat Commun, 13:2903-2903, 2022; PubMed: 35614066; DOI: 10.1038/s41467-022-30581-4

実験手法