7EFQ

Crystal structure of hPPARgamma ligand binding domain complexed with rosiglitazone-based fluorescence probe

7EFQ の概要

• エントリーDOI: 10.2210/pdb7efq/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (5S)-5-[[4-[2-[[7-(diethylamino)-2-oxidanylidene-chromen-4-yl]-methyl-amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione (3 entities in total)
• 機能のキーワード: ppargamma, rosiglitazone, coumarin, fluorescence probe, tzd, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63394.63

構造登録者

Yoshikawa, C.,Ishida, H.,Ohashi, N.,Itoh, T. (登録日: 2021-03-23, 公開日: 2021-05-12, 最終更新日: 2023-11-29)

• 主引用文献: Yoshikawa, C.,Ishida, H.,Ohashi, N.,Itoh, T.; Synthesis of a Coumarin-Based PPAR gamma Fluorescence Probe for Competitive Binding Assay.; Int J Mol Sci, 22:-, 2021; PubMed: 33919837; DOI: 10.3390/ijms22084034

実験手法

X-RAY DIFFRACTION (2.3 Å)