7EFP

Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (S19W,N330Y)

7EFP の概要

• エントリーDOI: 10.2210/pdb7efp/pdb
• 分子名称: Processed angiotensin-converting enzyme 2, Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: receptor-binding domain, angiotensin converting enzyme 2, viral protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95095.67

構造登録者

Lu, G.W.,Ye, F.,Lin, X. (登録日: 2021-03-22, 公開日: 2021-11-24, 最終更新日: 2023-11-29)

• 主引用文献: Ye, F.,Lin, X.,Chen, Z.,Yang, F.,Lin, S.,Yang, J.,Chen, H.,Sun, H.,Wang, L.,Wen, A.,Zhang, X.,Dai, Y.,Cao, Y.,Yang, J.,Shen, G.,Yang, L.,Li, J.,Wang, Z.,Wang, W.,Wei, X.,Lu, G.; S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis.; Signal Transduct Target Ther, 6:343-343, 2021; PubMed: 34531369; DOI: 10.1038/s41392-021-00756-4

実験手法

X-RAY DIFFRACTION (2.698 Å)