7E6Q
Crystal structure of influenza A virus neuraminidase N5 complexed with 4'-phenyl-1,2,3-triazolylated oseltamivir carboxylate
Summary for 7E6Q
Entry DOI | 10.2210/pdb7e6q/pdb |
Descriptor | Neuraminidase, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | influenza virus, neuraminidase inhibitors, oseltamivir derivatives, 150-cavity, hydrolase |
Biological source | Influenza A virus (strain A/Duck/Alberta/60/1976 H12N5) |
Total number of polymer chains | 2 |
Total formula weight | 88632.61 |
Authors | Wang, P.F.,Babayemi, O.O.,Li, C.N.,Fu, L.F.,Zhang, S.S.,Qi, J.X.,Lv, X.,Li, X.B. (deposition date: 2021-02-23, release date: 2021-03-17, Last modification date: 2023-11-29) |
Primary citation | Wang, P.,Oladejo, B.O.,Li, C.,Fu, L.,Zhang, S.,Qi, J.,Lv, X.,Li, X. Structure-based design of 5'-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors. Rsc Adv, 11:9528-9541, 2021 Cited by PubMed: 35423449DOI: 10.1039/d1ra00472g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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