7E6Q

Crystal structure of influenza A virus neuraminidase N5 complexed with 4'-phenyl-1,2,3-triazolylated oseltamivir carboxylate

7E6Q の概要

• エントリーDOI: 10.2210/pdb7e6q/pdb
• 分子名称: Neuraminidase, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: influenza virus, neuraminidase inhibitors, oseltamivir derivatives, 150-cavity, hydrolase
• 由来する生物種: Influenza A virus (strain A/Duck/Alberta/60/1976 H12N5)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88632.61

構造登録者

Wang, P.F.,Babayemi, O.O.,Li, C.N.,Fu, L.F.,Zhang, S.S.,Qi, J.X.,Lv, X.,Li, X.B. (登録日: 2021-02-23, 公開日: 2021-03-17, 最終更新日: 2023-11-29)

• 主引用文献: Wang, P.,Oladejo, B.O.,Li, C.,Fu, L.,Zhang, S.,Qi, J.,Lv, X.,Li, X.; Structure-based design of 5'-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors.; Rsc Adv, 11:9528-9541, 2021; PubMed: 35423449; DOI: 10.1039/d1ra00472g

実験手法

X-RAY DIFFRACTION (2.2 Å)