7E4P

Crystal structure of tubulin in complex with Ansamitocin P3

Summary for 7E4P

• Entry DOI: 10.2210/pdb7e4p/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate, ... (13 entities in total)
• Functional Keywords: microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Bos taurus (Bovine); More
• Total number of polymer chains: 6
• Total formula weight: 258466.02

Authors

Wang, Y.,Li, W. (deposition date: 2021-02-14, release date: 2022-02-16, Last modification date: 2023-11-29)

• Primary citation: Wang, Y.,Li, W.; C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)