7E4P

Crystal structure of tubulin in complex with Ansamitocin P3

7E4P の概要

• エントリーDOI: 10.2210/pdb7e4p/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate, ... (13 entities in total)
• 機能のキーワード: microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor
• 由来する生物種: Bos taurus (Bovine); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 258466.02

構造登録者

Wang, Y.,Li, W. (登録日: 2021-02-14, 公開日: 2022-02-16, 最終更新日: 2023-11-29)

• 主引用文献: Wang, Y.,Li, W.; C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids; To Be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)