7E0P

Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 4-(((6-Bromo-1H-indazol-4-yl)amino)methyl)phenol (2)

Summary for 7E0P

Entry DOI	10.2210/pdb7e0p/pdb
Descriptor	Indoleamine 2,3-dioxygenase 1, 4-[[(6-bromanyl-1~{H}-indazol-4-yl)amino]methyl]phenol, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
Functional Keywords	indoleamine 2, 3-dioxygenase 1, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	90150.87
Authors	Li, G.-B.,Ning, X.-L. (deposition date: 2021-01-28, release date: 2021-07-21, Last modification date: 2023-11-29)
Primary citation	Ning, X.L.,Li, Y.Z.,Huo, C.,Deng, J.,Gao, C.,Zhu, K.R.,Wang, M.,Wu, Y.X.,Yu, J.L.,Ren, Y.L.,Luo, Z.Y.,Li, G.,Chen, Y.,Wang, S.Y.,Peng, C.,Yang, L.L.,Wang, Z.Y.,Wu, Y.,Qian, S.,Li, G.B. X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. J.Med.Chem., 64:8303-8332, 2021 Cited by PubMed: 34110158 DOI: 10.1021/acs.jmedchem.1c00303 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.635 Å)

Structure validation