7DTZ

FGFR4 complex with a covalent inhibitor

Summary for 7DTZ

• Entry DOI: 10.2210/pdb7dtz/pdb
• Descriptor: Fibroblast growth factor receptor 4, N-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, covalent, crystal, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35112.23

Authors

Chen, X.J.,Dai, S.Y.,Chen, Y.H. (deposition date: 2021-01-07, release date: 2021-04-14, Last modification date: 2023-11-29)

• Primary citation: Deng, W.,Chen, X.,Jiang, K.,Song, X.,Huang, M.,Tu, Z.C.,Zhang, Z.,Lin, X.,Ortega, R.,Patterson, A.V.,Smaill, J.B.,Ding, K.,Chen, S.,Chen, Y.,Lu, X.; Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.; Acs Med.Chem.Lett., 12:647-652, 2021; PubMed: 33859803; DOI: 10.1021/acsmedchemlett.1c00052

Experimental method

X-RAY DIFFRACTION (2.01 Å)