7DPO
Crystal Structure of BRD2(BD2)with Ligand ZB-BD-224 bound
7DPO の概要
エントリーDOI | 10.2210/pdb7dpo/pdb |
分子名称 | Bromodomain-containing protein 2, 5-(1-naphthoyl)-11-methyl-8-((methylsulfonyl)methyl)-4,5-dihydro-2,3a1,5-triazadibenzo[cd,h]azulen-1(2H)-one (3 entities in total) |
機能のキーワード | antitumor; bet proteins; bromodomain inhibitor; epigenetic readers, antitumor protein |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 13681.71 |
構造登録者 | |
主引用文献 | Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zgou, B. Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.29994028999 Å) |
構造検証レポート
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