7DP6
Crystal structure of mutant V45T Brugia malayi thymidylate synthase complexed with 2'-deoxyuridine monophosphate
Summary for 7DP6
Entry DOI | 10.2210/pdb7dp6/pdb |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, ... (5 entities in total) |
Functional Keywords | thymidylate synthase, nucleotide synthase, transferase, methyltransferase |
Biological source | Brugia malayi (Filarial nematode worm) |
Total number of polymer chains | 1 |
Total formula weight | 35357.24 |
Authors | Keyunratsami, K.,Nualnoi, T.,Wongkamchai, S.,Songsiriritthigul, C.,Chen, C.-J.,Canyuk, B. (deposition date: 2020-12-18, release date: 2021-12-22, Last modification date: 2023-11-29) |
Primary citation | Keyunratsami, K.,Nualnoi, T.,Wongkamchai, S.,Songsiriritthigul, C.,Chen, C.-J.,Canyuk, B. Crystallographic investigation and inhibition of Brugia malayi thymidylate synthase by a folate analog To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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