7DMU

Structure of SARS-CoV-2 spike receptor-binding domain complexed with high affinity ACE2 mutant 3N39

7DMU の概要

• エントリーDOI: 10.2210/pdb7dmu/pdb
• 分子名称: Angiotensin-converting enzyme 2, Spike protein S1, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: sars-cov-2, covid-19, ace2, viral protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 196426.79

構造登録者

Arimori, T.,Takagi, J. (登録日: 2020-12-07, 公開日: 2020-12-23, 最終更新日: 2023-11-29)

• 主引用文献: Higuchi, Y.,Suzuki, T.,Arimori, T.,Ikemura, N.,Mihara, E.,Kirita, Y.,Ohgitani, E.,Mazda, O.,Motooka, D.,Nakamura, S.,Sakai, Y.,Itoh, Y.,Sugihara, F.,Matsuura, Y.,Matoba, S.,Okamoto, T.,Takagi, J.,Hoshino, A.; Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2.; Nat Commun, 12:3802-3802, 2021; PubMed: 34155214; DOI: 10.1038/s41467-021-24013-y

実験手法

X-RAY DIFFRACTION (3.2 Å)