7DIJ

Falcilysin in complex with MK-4815

Summary for 7DIJ

• Entry DOI: 10.2210/pdb7dij/pdb
• Related: 7DI7
• Descriptor: Falcilysin, GLYCEROL, ACETATE ION, ... (8 entities in total)
• Functional Keywords: protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Plasmodium falciparum 3D7
• Total number of polymer chains: 1
• Total formula weight: 135873.70

Authors

Lin, J.Q.,El Sahili, A.,Lescar, J. (deposition date: 2020-11-19, release date: 2021-12-01, Last modification date: 2024-05-29)

• Primary citation: Wirjanata, G.,Lin, J.,Dziekan, J.M.,El Sahili, A.,Chung, Z.,Tjia, S.,Binte Zulkifli, N.E.,Boentoro, J.,Tham, R.,Jia, L.S.,Go, K.D.,Yu, H.,Partridge, A.,Olsen, D.,Prabhu, N.,Sobota, R.M.,Nordlund, P.,Lescar, J.,Bozdech, Z.; Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.; Cell Chem Biol, 31:743-759.e8, 2024; PubMed: 38593807; DOI: 10.1016/j.chembiol.2024.03.002

Experimental method

X-RAY DIFFRACTION (1.9 Å)