7DHL
Crystal structure of FGFR3 in complex with pyrimidine derivative
Summary for 7DHL
Entry DOI | 10.2210/pdb7dhl/pdb |
Descriptor | Fibroblast growth factor receptor 3, 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine (3 entities in total) |
Functional Keywords | protein kinase, signaling protein, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36211.44 |
Authors | Echizen, Y.,Tateishi, Y.,Amano, Y. (deposition date: 2020-11-16, release date: 2021-02-03, Last modification date: 2023-11-29) |
Primary citation | Kuriwaki, I.,Kameda, M.,Iikubo, K.,Hisamichi, H.,Kawamoto, Y.,Kikuchi, S.,Moritomo, H.,Kondoh, Y.,Terasaka, T.,Amano, Y.,Tateishi, Y.,Echizen, Y.,Iwai, Y.,Noda, A.,Tomiyama, H.,Nakazawa, T.,Hirano, M. Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency. Bioorg.Med.Chem., 33:116019-116019, 2021 Cited by PubMed: 33486159DOI: 10.1016/j.bmc.2021.116019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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