7DHL

Crystal structure of FGFR3 in complex with pyrimidine derivative

7DHL の概要

• エントリーDOI: 10.2210/pdb7dhl/pdb
• 分子名称: Fibroblast growth factor receptor 3, 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine (3 entities in total)
• 機能のキーワード: protein kinase, signaling protein, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36211.44

構造登録者

Echizen, Y.,Tateishi, Y.,Amano, Y. (登録日: 2020-11-16, 公開日: 2021-02-03, 最終更新日: 2023-11-29)

• 主引用文献: Kuriwaki, I.,Kameda, M.,Iikubo, K.,Hisamichi, H.,Kawamoto, Y.,Kikuchi, S.,Moritomo, H.,Kondoh, Y.,Terasaka, T.,Amano, Y.,Tateishi, Y.,Echizen, Y.,Iwai, Y.,Noda, A.,Tomiyama, H.,Nakazawa, T.,Hirano, M.; Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.; Bioorg.Med.Chem., 33:116019-116019, 2021; PubMed: 33486159; DOI: 10.1016/j.bmc.2021.116019

実験手法

X-RAY DIFFRACTION (2.57 Å)