7DFY

Novel motif for left-handed G-quadruplex formation

7DFY の概要

• エントリーDOI: 10.2210/pdb7dfy/pdb
• 分子名称: 2xMotif2, POTASSIUM ION, STRONTIUM ION, ... (5 entities in total)
• 機能のキーワード: left-handed, g-quadruplex, bulge, four-layer, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 17865.36

構造登録者

Das, P.,Winnerdy, F.R.,Maity, A.,Mechulam, Y.,Phan, A.T. (登録日: 2020-11-10, 公開日: 2021-09-01, 最終更新日: 2023-11-29)

主引用文献

Das, P.,Winnerdy, F.R.,Maity, A.,Mechulam, Y.,Phan, A.T.
A novel minimal motif for left-handed G-quadruplex formation.
Chem.Commun.(Camb.), 57:2527-2530, 2021

PubMed Abstract: A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

PubMed: 33690751
DOI: 10.1039/d0cc08146a

実験手法

X-RAY DIFFRACTION (1.69 Å)