7DFR

CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE

7DFR の概要

• エントリーDOI: 10.2210/pdb7dfr/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: oxido-reductase, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19205.13

構造登録者

Bystroff, C.,Oatley, S.J.,Kraut, J. (登録日: 1988-10-21, 公開日: 1990-07-15, 最終更新日: 2017-11-29)

• 主引用文献: Bystroff, C.,Oatley, S.J.,Kraut, J.; Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.; Biochemistry, 29:3263-3277, 1990; PubMed: 2185835; DOI: 10.1021/bi00465a018

実験手法

X-RAY DIFFRACTION (2.5 Å)