7DDC

Crystal structure of SARS-CoV-2 main protease in complex with Tafenoquine

7DDC の概要

• エントリーDOI: 10.2210/pdb7ddc/pdb
• 分子名称: 3C-like proteinase, Tafenoquine (3 entities in total)
• 機能のキーワード: main protease, 3c-like proteinase, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34346.09

構造登録者

Chen, Y.,Wang, Y.C.,Yang, C.S.,Hung, M.C. (登録日: 2020-10-28, 公開日: 2021-11-10, 最終更新日: 2023-11-29)

• 主引用文献: Chen, Y.,Yang, W.H.,Chen, H.F.,Huang, L.M.,Gao, J.Y.,Lin, C.W.,Wang, Y.C.,Yang, C.S.,Liu, Y.L.,Hou, M.H.,Tsai, C.L.,Chou, Y.Z.,Huang, B.Y.,Hung, C.F.,Hung, Y.L.,Wang, W.J.,Su, W.C.,Kumar, V.,Wu, Y.C.,Chao, S.W.,Chang, C.S.,Chen, J.S.,Chiang, Y.P.,Cho, D.Y.,Jeng, L.B.,Tsai, C.H.,Hung, M.C.; Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2.; J.Biol.Chem., 298:101658-101658, 2022; PubMed: 35101449; DOI: 10.1016/j.jbc.2022.101658

実験手法

X-RAY DIFFRACTION (2.175 Å)