7DB7

Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001

7DB7 の概要

• エントリーDOI: 10.2210/pdb7db7/pdb
• 関連するPDBエントリー: 7DAW
• 分子名称: Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea, ... (5 entities in total)
• 機能のキーワード: aminoacylation, trna-binding, aminoacyl-trna synthetase, atp-binding, ligase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129189.35

構造登録者

Xu, M.,Zhang, X.,Xu, L.,Chen, S. (登録日: 2020-10-19, 公開日: 2021-01-13, 最終更新日: 2023-11-29)

• 主引用文献: Wang, H.,Xu, M.,Engelhart, C.A.,Zhang, X.,Yan, B.,Pan, M.,Xu, Y.,Fan, S.,Liu, R.,Xu, L.,Hua, L.,Schnappinger, D.,Chen, S.; Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .; J.Biol.Chem., 2021; PubMed: 33397709; DOI: 10.1074/jbc.RA120.016477

実験手法

X-RAY DIFFRACTION (2.71 Å)