7D85
Crystal structure of anti-ErbB3 Fab ISU104 in complex with human ErbB3 extracellular domain 3
Summary for 7D85
Entry DOI | 10.2210/pdb7d85/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-3, Anti-ErbB3 Fab heavy chain, Anti-ErbB3 Fab light chain, ... (5 entities in total) |
Functional Keywords | transferase/immune system, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 138361.48 |
Authors | |
Primary citation | Hong, M.,Yoo, Y.,Kim, M.,Kim, J.Y.,Cha, J.S.,Choi, M.K.,Kim, U.,Kim, K.,Sohn, Y.,Bae, D.,Cho, H.S.,Hong, S.B. A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization. Mol.Cancer Ther., 20:1142-1152, 2021 Cited by PubMed: 33782100DOI: 10.1158/1535-7163.MCT-20-0907 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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