7D85

Crystal structure of anti-ErbB3 Fab ISU104 in complex with human ErbB3 extracellular domain 3

Summary for 7D85

• Entry DOI: 10.2210/pdb7d85/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-3, Anti-ErbB3 Fab heavy chain, Anti-ErbB3 Fab light chain, ... (5 entities in total)
• Functional Keywords: transferase/immune system, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 138361.48

Authors

Yoo, Y.,Cho, H.S. (deposition date: 2020-10-07, release date: 2021-04-07, Last modification date: 2021-06-16)

• Primary citation: Hong, M.,Yoo, Y.,Kim, M.,Kim, J.Y.,Cha, J.S.,Choi, M.K.,Kim, U.,Kim, K.,Sohn, Y.,Bae, D.,Cho, H.S.,Hong, S.B.; A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization.; Mol.Cancer Ther., 20:1142-1152, 2021; PubMed: 33782100; DOI: 10.1158/1535-7163.MCT-20-0907

Experimental method

X-RAY DIFFRACTION (2.5 Å)