7D85

Crystal structure of anti-ErbB3 Fab ISU104 in complex with human ErbB3 extracellular domain 3

7D85 の概要

• エントリーDOI: 10.2210/pdb7d85/pdb
• 分子名称: Receptor tyrosine-protein kinase erbB-3, Anti-ErbB3 Fab heavy chain, Anti-ErbB3 Fab light chain, ... (5 entities in total)
• 機能のキーワード: transferase/immune system, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 138361.48

構造登録者

Yoo, Y.,Cho, H.S. (登録日: 2020-10-07, 公開日: 2021-04-07, 最終更新日: 2021-06-16)

• 主引用文献: Hong, M.,Yoo, Y.,Kim, M.,Kim, J.Y.,Cha, J.S.,Choi, M.K.,Kim, U.,Kim, K.,Sohn, Y.,Bae, D.,Cho, H.S.,Hong, S.B.; A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization.; Mol.Cancer Ther., 20:1142-1152, 2021; PubMed: 33782100; DOI: 10.1158/1535-7163.MCT-20-0907

実験手法

X-RAY DIFFRACTION (2.5 Å)