7D4X

X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0

7D4X の概要

• エントリーDOI: 10.2210/pdb7d4x/pdb
• 分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: dihydrofolate, reductase, alpha-beta sandiwitch, nadph, oxidoreductase
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19205.13

構造登録者

Wan, Q.,Dealwis, C. (登録日: 2020-09-24, 公開日: 2021-06-09, 最終更新日: 2023-11-29)

• 主引用文献: Wan, Q.,Bennett, B.C.,Wymore, T.,Li, Z.,Wilson, M.A.,Brooks III, C.L.,Langan, P.,Kovalevsky, A.,Dealwis, C.G.; Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis; Acs Catalysis, 11:5873-5884, 2021; DOI: 10.1021/acscatal.1c00417

実験手法

X-RAY DIFFRACTION (1.599 Å)