7D3Z
X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5
Summary for 7D3Z
| Entry DOI | 10.2210/pdb7d3z/pdb |
| Descriptor | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
| Functional Keywords | dihydrofolate, reductase, alpha-beta sandiwitch, nadph, oxidoreductase |
| Biological source | Escherichia coli (strain K12) |
| Total number of polymer chains | 1 |
| Total formula weight | 19205.13 |
| Authors | Wan, Q.,Dealwis, C. (deposition date: 2020-09-21, release date: 2021-06-09, Last modification date: 2023-11-29) |
| Primary citation | Wan, Q.,Bennett, B.C.,Wymore, T.,Li, Z.,Wilson, M.A.,Brooks III, C.L.,Langan, P.,Kovalevsky, A.,Dealwis, C. Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11:5873-5884, 2021 Cited by DOI: 10.1021/acscatal.1c00417PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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