7D3C

The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease

Summary for 7D3C

• Entry DOI: 10.2210/pdb7d3c/pdb
• Related PRD ID: PRD_002214
• Descriptor: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• Functional Keywords: mers-cov, nsp5, n3, viral protein
• Biological source: Middle East respiratory syndrome-related coronavirus (MERS-CoV); More
• Total number of polymer chains: 4
• Total formula weight: 68071.90

Authors

Yan, L.,Ren, Z. (deposition date: 2020-09-18, release date: 2021-11-03, Last modification date: 2023-11-29)

• Primary citation: Ren, Z.,Yan, L.,Zhang, N.,Guo, Y.,Yang, C.,Lou, Z.,Rao, Z.; The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease; Protein cell, 4:248-250, 2013; PubMed: 23549610; DOI: 10.1007/s13238-013-2841-3

Experimental method

X-RAY DIFFRACTION (2.2 Å)