7D3C

The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease

7D3C の概要

• エントリーDOI: 10.2210/pdb7d3c/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002214
• 分子名称: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• 機能のキーワード: mers-cov, nsp5, n3, viral protein
• 由来する生物種: Middle East respiratory syndrome-related coronavirus (MERS-CoV); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 68071.90

構造登録者

Yan, L.,Ren, Z. (登録日: 2020-09-18, 公開日: 2021-11-03, 最終更新日: 2024-10-16)

• 主引用文献: Ren, Z.,Yan, L.,Zhang, N.,Guo, Y.,Yang, C.,Lou, Z.,Rao, Z.; The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease; Protein cell, 4:248-250, 2013; PubMed: 23549610; DOI: 10.1007/s13238-013-2841-3

実験手法

X-RAY DIFFRACTION (2.2 Å)