7D2K
Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a
Summary for 7D2K
Entry DOI | 10.2210/pdb7d2k/pdb |
Descriptor | Transient receptor potential cation channel subfamily V member 6, CALCIUM ION, 1-(5-bromanylpyridin-3-yl)-4-[4-(3-methylphenyl)cyclohexyl]piperazin-4-ium (3 entities in total) |
Functional Keywords | ion channels, trp channels, membrane proteins, transport protein-inhibitor complex, transport protein/inhibitor |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 1 |
Total formula weight | 78004.35 |
Authors | Singh, A.K.,Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2020-09-16, release date: 2021-10-06, Last modification date: 2023-11-29) |
Primary citation | Bhardwaj, R.,Lindinger, S.,Neuberger, A.,Nadezhdin, K.D.,Singh, A.K.,Cunha, M.R.,Derler, I.,Gyimesi, G.,Reymond, J.L.,Hediger, M.A.,Romanin, C.,Sobolevsky, A.I. Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6:-, 2020 Cited by PubMed: 33246965DOI: 10.1126/sciadv.abe1508 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.698 Å) |
Structure validation
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