7CWC
Ambient-Temperature Serial Femtosecond X-ray Crystal structure of SARS-CoV-2 Main Protease at 2.1 A Resolution (P212121)
Summary for 7CWC
Entry DOI | 10.2210/pdb7cwc/pdb |
Related | 7WCB |
Descriptor | 3C-like proteinase (2 entities in total) |
Functional Keywords | covid19, sars-cov-2, drug target, serial femtosecond x-ray crystallography, sfx, xfel, virus protein, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 2 |
Total formula weight | 68478.03 |
Authors | DeMirci, H. (deposition date: 2020-08-27, release date: 2020-09-30, Last modification date: 2023-11-29) |
Primary citation | Durdagi, S.,Dag, C.,Dogan, B.,Yigin, M.,Avsar, T.,Buyukdag, C.,Erol, I.,Ertem, F.B.,Calis, S.,Yildirim, G.,Orhan, M.D.,Guven, O.,Aksoydan, B.,Destan, E.,Sahin, K.,Besler, S.O.,Oktay, L.,Shafiei, A.,Tolu, I.,Ayan, E.,Yuksel, B.,Peksen, A.B.,Gocenler, O.,Yucel, A.D.,Can, O.,Ozabrahamyan, S.,Olkan, A.,Erdemoglu, E.,Aksit, F.,Tanisali, G.,Yefanov, O.M.,Barty, A.,Tolstikova, A.,Ketawala, G.K.,Botha, S.,Dao, E.H.,Hayes, B.,Liang, M.,Seaberg, M.H.,Hunter, M.S.,Batyuk, A.,Mariani, V.,Su, Z.,Poitevin, F.,Yoon, C.H.,Kupitz, C.,Sierra, R.G.,Snell, E.H.,DeMirci, H. Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing. Structure, 29:1382-1396.e6, 2021 Cited by PubMed: 34403647DOI: 10.1016/j.str.2021.07.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report