7CSI

Aminoglycoside 2'-N-acetyltransferase from Mycolicibacterium smegmatis-Complex with Coenzyme A and Sisomicin

Summary for 7CSI

• Entry DOI: 10.2210/pdb7csi/pdb
• Related: 7CRM
• Descriptor: Aminoglycoside 2'-N-acetyltransferase, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, COENZYME A, ... (4 entities in total)
• Functional Keywords: aminoglycoside acetyltransferase, antibiotics, sisomicin, transferase
• Biological source: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
• Total number of polymer chains: 2
• Total formula weight: 48827.80

Authors

Jeong, C.S.,Hwang, J.,Do, H.,Lee, J.H. (deposition date: 2020-08-14, release date: 2021-06-23, Last modification date: 2023-11-29)

• Primary citation: Jeong, C.S.,Hwang, J.,Do, H.,Cha, S.S.,Oh, T.J.,Kim, H.J.,Park, H.H.,Lee, J.H.; Structural and biochemical analyses of an aminoglycoside 2'-N-acetyltransferase from Mycolicibacterium smegmatis.; Sci Rep, 10:21503-21503, 2020; PubMed: 33299080; DOI: 10.1038/s41598-020-78699-z

Experimental method

X-RAY DIFFRACTION (1.89 Å)