7CP0
Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase
Summary for 7CP0
Entry DOI | 10.2210/pdb7cp0/pdb |
Descriptor | Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | glutaminyl-peptide cyclotransferase, sqc, alzheimer's disease, pyroglutamate, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 113781.21 |
Authors | Dileep, K.V.,Ihara, K.,Sakai, N.,Shirozu, M.,Zhang, K.Y.J. (deposition date: 2020-08-05, release date: 2021-01-13, Last modification date: 2023-11-29) |
Primary citation | Dileep, K.V.,Sakai, N.,Ihara, K.,Kato-Murayama, M.,Nakata, A.,Ito, A.,Sivaraman, D.M.,Shin, J.W.,Yoshida, M.,Shirouzu, M.,Zhang, K.Y.J. Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors. Int.J.Biol.Macromol., 170:415-423, 2020 Cited by PubMed: 33373636DOI: 10.1016/j.ijbiomac.2020.12.118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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