7CKW

Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex

7CKW の概要

• エントリーDOI: 10.2210/pdb7ckw/pdb
• EMDBエントリー: 30392
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: transmembrane protein, signaling transduction, cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 160553.94

構造登録者

Yan, W.,Shao, W. (登録日: 2020-07-20, 公開日: 2021-03-03)

• 主引用文献: Xiao, P.,Yan, W.,Gou, L.,Zhong, Y.N.,Kong, L.,Wu, C.,Wen, X.,Yuan, Y.,Cao, S.,Qu, C.,Yang, X.,Yang, C.C.,Xia, A.,Hu, Z.,Zhang, Q.,He, Y.H.,Zhang, D.L.,Zhang, C.,Hou, G.H.,Liu, H.,Zhu, L.,Fu, P.,Yang, S.,Rosenbaum, D.M.,Sun, J.P.,Du, Y.,Zhang, L.,Yu, X.,Shao, Z.; Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.; Cell, 184:943-956.e18, 2021; PubMed: 33571432; DOI: 10.1016/j.cell.2021.01.028

実験手法

ELECTRON MICROSCOPY (3.22 Å)