7CGW

Complex structure of PD-1 and tislelizumab Fab

Summary for 7CGW

Entry DOI	10.2210/pdb7cgw/pdb
Descriptor	Heavy chain of tislelizumab Fab, Light chain of tislelizumab Fab, Programmed cell death protein 1, ... (4 entities in total)
Functional Keywords	tislelizumab, pd-1, antibody, antitumor protein
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	131561.07
Authors	Hong, Y.,Feng, Y.C.,Liu, Y. (deposition date: 2020-07-02, release date: 2021-04-07, Last modification date: 2024-04-03)
Primary citation	Hong, Y.,Feng, Y.,Sun, H.,Zhang, B.,Wu, H.,Zhu, Q.,Li, Y.,Zhang, T.,Zhang, Y.,Cui, X.,Li, Z.,Song, X.,Li, K.,Liu, M.,Liu, Y. Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. Febs Open Bio, 11:782-792, 2021 Cited by PubMed: 33527708 DOI: 10.1002/2211-5463.13102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation