7CGW

Complex structure of PD-1 and tislelizumab Fab

7CGW の概要

• エントリーDOI: 10.2210/pdb7cgw/pdb
• 分子名称: Heavy chain of tislelizumab Fab, Light chain of tislelizumab Fab, Programmed cell death protein 1, ... (4 entities in total)
• 機能のキーワード: tislelizumab, pd-1, antibody, antitumor protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 131561.07

構造登録者

Hong, Y.,Feng, Y.C.,Liu, Y. (登録日: 2020-07-02, 公開日: 2021-04-07, 最終更新日: 2024-04-03)

• 主引用文献: Hong, Y.,Feng, Y.,Sun, H.,Zhang, B.,Wu, H.,Zhu, Q.,Li, Y.,Zhang, T.,Zhang, Y.,Cui, X.,Li, Z.,Song, X.,Li, K.,Liu, M.,Liu, Y.; Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage.; Febs Open Bio, 11:782-792, 2021; PubMed: 33527708; DOI: 10.1002/2211-5463.13102

実験手法

X-RAY DIFFRACTION (3.2 Å)