7CFN

Cryo-EM structure of the INT-777-bound GPBAR-Gs complex

7CFN の概要

• エントリーDOI: 10.2210/pdb7cfn/pdb
• EMDBエントリー: 30345
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (9 entities in total)
• 機能のキーワード: gpcr, gpbar, complex, bile acid, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 142181.87

構造登録者

Yang, F.,Mao, C.,Guo, L.,Lin, J.,Ming, Q.,Xiao, P.,Wu, X.,Shen, Q.,Guo, S.,Shen, D.,Lu, R.,Zhang, L.,Huang, S.,Ping, Y.,Zhang, C.,Ma, C.,Zhang, K.,Liang, X.,Shen, Y.,Nan, F.,Yi, F.,Luca, V.,Zhou, J.,Jiang, C.,Sun, J.,Xie, X.,Yu, X.,Zhang, Y. (登録日: 2020-06-27, 公開日: 2020-09-09, 最終更新日: 2021-04-07)

• 主引用文献: Yang, F.,Mao, C.,Guo, L.,Lin, J.,Ming, Q.,Xiao, P.,Wu, X.,Shen, Q.,Guo, S.,Shen, D.D.,Lu, R.,Zhang, L.,Huang, S.,Ping, Y.,Zhang, C.,Ma, C.,Zhang, K.,Liang, X.,Shen, Y.,Nan, F.,Yi, F.,Luca, V.C.,Zhou, J.,Jiang, C.,Sun, J.P.,Xie, X.,Yu, X.,Zhang, Y.; Structural basis of GPBAR activation and bile acid recognition.; Nature, 587:499-504, 2020; PubMed: 32698187; DOI: 10.1038/s41586-020-2569-1

実験手法

ELECTRON MICROSCOPY (3 Å)