7CEK
Crystal structure of T2R-TTL-BML-284 complex
Summary for 7CEK
| Entry DOI | 10.2210/pdb7cek/pdb |
| Descriptor | Tubulin alpha-1B chain, N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine, CHLORIDE ION, ... (13 entities in total) |
| Functional Keywords | tubulin inhibitor, tublin, structural protein-inhibitor complex |
| Biological source | Rattus norvegicus (Rat) More |
| Total number of polymer chains | 6 |
| Total formula weight | 265116.35 |
| Authors | Chen, L.J.,Chen, Q.,Yu, Y.,Yang, J.H. (deposition date: 2020-06-23, release date: 2021-06-23, Last modification date: 2023-11-29) |
| Primary citation | Yang, J.,Li, Y.,Qiu, Q.,Wang, R.,Yan, W.,Yu, Y.,Niu, L.,Pei, H.,Wei, H.,Ouyang, L.,Ye, H.,Xu, D.,Wei, Y.,Chen, Q.,Chen, L. Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J.Med.Chem., 65:9159-9173, 2022 Cited by PubMed: 35762925DOI: 10.1021/acs.jmedchem.2c00379 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.696 Å) |
Structure validation
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