7CE4

Tankyrase2 catalytic domain in complex with K-476

Summary for 7CE4

• Entry DOI: 10.2210/pdb7ce4/pdb
• Descriptor: Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION, SULFATE ION, ... (7 entities in total)
• Functional Keywords: tankyrase, parp, adp-ribosylation, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28322.12

Authors

Takahashi, Y.,Suzuki, M.,Saito, J. (deposition date: 2020-06-22, release date: 2021-05-12, Last modification date: 2023-11-29)

• Primary citation: Kinosada, H.,Okada-Iwasaki, R.,Kunieda, K.,Suzuki-Imaizumi, M.,Takahashi, Y.,Miyagi, H.,Suzuki, M.,Motosawa, K.,Watanabe, M.,Mie, M.,Ishii, T.,Ishida, H.,Saito, J.I.,Nakai, R.; The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8 + T cells to tumors.; Am J Cancer Res, 11:264-276, 2021; PubMed: 33520373

Experimental method

X-RAY DIFFRACTION (1.5 Å)